aphilipmarcou, just like any other threaded joint, you can use blue, or non-permanent, locking compound on the threads. It can still be snugged up later, if needed. A hub/flange ass'y in good condition will spin tighter to a grinding wheel than many people would think. If the spindle on the surface grinder isn't in perfect shape, the rotation of the hub to shaft is critical.
Also, for dry operations, paper flange gaskets work fine. They only shrink after an extended period, where further tightening will solve the issue. For wet grinding, I found the plastic or impregnated paper gaskets are better suited.
Again, I've had 6" to 14" formed wheels for ages that I saved for repeated touch up work, or venting on a mold cavity. Soft-starting kept the wheel in check. Any heavy grinding will still require a redress.

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