Not to usurp thehomeengineer, allow me provide an explanation. This is an effective clamp, secure enough to withstand milling and drilling; be aware burying a helical [right-hand cut, right-hand helix] cutting edge can pull the plate up. One technique uses right-hand cut with a left-hand helix to generate down force.
Off center in one axis is sufficient. Knowing the amount, it moves the hexagon laterally an equal amount on any face; one needs to pick that which locks against the part before the cam goes over center. The rail or hard stop of opposite side does the rest.
A bi-axial offcenter would produce same result, without benefit, as the cam's rotation is in the entire round bearing area. They could be round instead of hexagon; moving the same distance, but too little contact area for dependable clamp action.
A commercial version is known as Mitee-Bite

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