I got frustrated at not being able to find things and decided to turn over a new leaf for me and organize my tools and supplies more or less grouped by their primary usage. I found that it had an immediate positive impact on the time it took because I wasn't spending all that time looking for things. Extending that I've adopted the procedure that once I've used a thing I immediately put it back where it goes and this improved my workflow more, since it takes little time to put something back from where you just got it and it eliminates most of the time spent at the end of the session returning things and my work sessions are more productive and less aggravating because of it. I can imagine with a collection as extensive as yours that a significant amount of time could be spent looking for stuff.