Before it reaches any runway, it has to be built. Upon X amount of hours it'll need service.
Do any buildings accommodate such a profile? Current hangers have a comparatively small set of secondary doors for vertical stabilizer, that might be half the height depicted here. Not to mention scissor lifts work to position airframe and powerplant techs; this will need man-bucket boom trucks as well.
I'm no aeronautic engineer, but cannot visualize what lifting airfoil contour works on the "sides" of the torus. Then upper and lower portion seem not to offer surface area equivalent to a conventional fuselage, unless takeoff weight is perhaps halved.
Regarding current methods of building wing spars, well that's going to invalidate all kinds of capital equipment.