IIRC you have linear ball slides on the Z axis, that is very low friction. I am guessing but I do not believe this is a good match to a normal lead screw. Maybe you need a ball screw. Like I said this is a guess, but the forces provided by the slide friction from normal dovetails will relieve load off the lead screw and nut on the way down.
I am currently building a CNC surface grinder which with a change of grinding head to a milling spindle will also be a 3 axes mill. I am using linear rails and ball screws on each axis. However as it is a work in progress it is too early to come to any conclusions about vibration. I have my fingers crossed.
Here is an idea. On my Bridgeport mill I have added 4 assist springs to the knee to relieve load off the stock screw and nut. Here is post that I made A knee helper
maybe something like that would work for you???????

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